THERAPY WITH A.U.I.T. (autogenous
- Courtesy of Wm. Hitt, M.D.,Ph.D.
(our clinical collegue)
- A.U.I.T. has a long term history of
benefit. Used for over 15 years by sevral physicians in the U.S.and
taught in immunology courses at Johns Hopkins, it is primarily
being done in clinics outside the U.S. now by William Hitt, M.D.,Ph.D.,
retired Professor of Immunology from Johns Hopkins and LSU for
over 13 years. He is not in private practice & "semi-retired"
in Tijuana, primarily working with the WHO in Addictions research
& Immunogenetics. The mechanism of action in this particular
type of therapy is similar to Hannemann's Homeopathic law of
cure...Like Cures Like. He is one of our clinical consulting
collegues and a friend...
- AUIT has been found clinically effective
in the treatment of the following conditions:
- ATOPIC DISEASES (reaction occurs in a distant area from contact
- HAYFEVER, GASTROENTERITIS, DERMATITIS,
- FOOD ALLERGY / INTOLERANCE
- STOMACH ACHES, RASHES, HEADACHES, DIARRHEA,
I.B.S., CROHNS, ASTHMA, ARTHRITIS, ETC.
- CHEMICAL SENSITIVITIES & INTOLERANCE
- HEADACHES, MIGRAINES, RASHES, ASTHMA,
CROHN'S, IRRITABLE BOWEL, ARTHRITIS, ETC.
- AUTOIMMUNE DISEASE
- LUPUS, M.S., PARKINSONS, ARTHRITIS,
SCLERODERMA, RAYNAUDS SYNDROME, PSORIASIS, DIABETES,
- IMMUNE SUPRESSION
- CANCER, HIV & RELATED SYNDROMES,
- INFECTIOUS DISEASE
- HIV, HERPES, HEP, HPV, MYCOPLASMA INFECTIONS,
- There is a multiplicity of compliated
mechanisms involved. Indeed, uirine contains many immunologically
active substances, some antigen-specific, some antigen-independent.
Both enhancer and suppressor substances are present. The term
"immumodulators" serves well to describe the mechanism
of action with AUIT.
- TYPE I Hypersensitivity
- Many B-lymphocytes exhibit surfact
antibodies--IgG and IgM. These antibodies differ from circulating
antibodies in 2 aspects: 1. They are smaller and in the case
of IgM are monomers rather than pentamers. IgG is suppressor,
and IgM is enhancer. IgG is controlled by two T-Cell supressor
factors (TSF & TSP2).
- When a B-Cell is stimulated--directed
or indirectly--by the proper antigen, surface immunoglobulins
multiply and polarize as switching occurs (surface Ig is replaced
by specific Ig, which the B-Cell produces and, eventually is
secreted by plasma cells), the B-Cell then sheds these surface
Ig's. They then circulate; some are metabolized, but a significant
amount appear in the urine via glomulaar filtration, where they
are cross-linked and denatured (urea, proteases).
- When reinjected into the adipose tissue
(fatty), they ABORT AN ALLERGENIC REACTION IN PROGRESS (i.e.
asthma attack) and, as memory cells are produced by REPEATED
INJECTIONS, (8-12 or more), a prolonged STATE OF NON-REACTIVITY
(Tolerance) is produced. The mechanism of action is dual...One
is the immediate stimulation of T-suppressor cells to produce
TS1 and TS2. The second long range action is the production of
an anti-idiotypes as well as supressor factors to other antibody-dependent
reactions, such as auto-immune disease or drug or transfusion
or rejection responses.
- TYPE II AND TYPE III (delated sensitivity)
- So-called intlerances to foods, chemicals,
etc. are mostly antigen-dependent BUT NOT ANTIBODY DEPENDENT(although
antibodies are often produced, they become mostly "innocent
bystanders".) We're dealing here with the cellular immune
system. Phagocytic cells and lymphokines play a very important
- Neutrophils, in particular are affected
in these reactions. NEUTROPHILS NOT ONLYPHAGOCYTISE LARGE SUBSTANCES
(PROTEINS), BUT ALSO ABSORB FOREIGN CHEMICAL SUBSTANCES (insecticides,
pesticides, mycotoxins, etc.). Neutrophils are under autonomous
and/or outside control. T-Cell, macrophages and cytokines sensitize
neutrophils to the point where they become hypersensitive to
a given substance(s) and over-react and eventually suffer damage
or destruction. AUIT supresses these reactions by regulating
#1, autonomous reactions of theneutrophils and #2, suppressing
the production of cytokines.
- VIRAL SYNDROMES
- INTERFERON: The mode of action againse
viral infections is due to the antiviral effect of the interferons,
Interferon Gamma (IFNg) is the most active one in this respect.
Cells have IFN receptors on their surfaces. When IFNg attaches
to them, it is internalized. Interferon-gamma then acts as an
anti-replicator. Interferons also inhibit mitosis (division)
of infected cells. INF receptors once internalized, DO NOT REPRODUCE.
Usually, about 40% of receptors are left on the cell surface.
- INTERLUKINS: Another immunomodulator
closely related in these activities is Interlukin-1 (IL-1). IL1
has to be renewed by the proper stimulant in order to cause its
effects. Therefore, the cliical observation that AUIT controls
but does not kill (cure) infected cells, is supported by immunological
- Much has been said in the past by critics
of AUIT--who, by the way, have no personal experience with this
type of therapy--regarding the danger of producing glomerula
basement membrane disease (Goodpasturer's disease). In some experimental
models using animals, such a disease has been produced using
the injection of urine, often in previously sensitized animals.
However, in close to a million injections of urine in humans
in both Texas and So. Calif. clinics, not a single case of Goodpasture's
disease, marked proteinuria or hematuria (all patients undergo
a urinalysis prior to the injection of the urine) has been observed.
Furthermore, in 5 cases of long-term (more than 1 year) of AUIT,
no glomerular basement membrane antigen was found in the blood.
- The objection to the presense of the
CBM antigen in the urine of many normal individuals can easily
be overcome by the removal of this antigen by filtration. The
antigen has a MW of 80,000 daltons, which is the limit of glomerular
filtration. Removing all substances heaver than MW 60,000 daltons
would leave all the immunomodulators and remove the CBM antigen.
The other critism of AUIT is that the urine does not posess immunologically-active
substances. This statement is so patently false, that only someone
alarmingly ignorant of even the basic facts of immunology can
- It is suggested that in order to elevate
AUIT to an "up-do-date" incontrovertible therapeutic
modality, the following studies must be undertaken:
- 1. A double-blind, randomized, placebo,
controlled study in cases of atopic disease
- 2. Measurement of IL, production of
IL2, Receptor numbers, Interferon production before and after
- 3. Publication in journals and dissemination
of the findings to the Medical and Lay communities...especially
as it refers to AIDS
- Auto-urine Therapy; 1984, Martin Krebs,
- Auto-urine Vaccine therapy for acute
Hemorrhagic Nephritis, 1934, R. Tiberi, M.D.
- Urine Therapy, Prof. Lish. J. Plesch,
M.D., 1947 English Medical Journal,l
- The Effects of Human Urine on Tubercule
Bacilli, 1951, Sweden
- Bacterial Effects of URE, Tulane School
of Medicine, 1961
- Antibacterial Effects of Human Urine,
1968, Dr. Donald Kaye, Cornell Univ. Med. College
- Neutralizing Antibody to Polioviruses
in Normal Urine, 1962, Lesner, Remington, Maxwell, Finland, Harvard
- AntiNeoplaston in Cancer Therapy, Stanislaw
- The Use of Injected and Subligual Urine
in Allergy Therapy, 1981, Nancy Dunne, M.D.
- Immuno-Tollerance, Physicians Handbook,
- Autoimmuno-therapy Against Human Allergenic
Disease, a physiological self-defense factor, 1983, C.W.M. Wilson,
& A. Lend, M.D.
- Bactericidal Properties of Urine for
Neisseric Gonurrhuae, 1987, Robert Noble, M.D. & M.Darekh,
M.S., Univ. Kentucky
- The Role of Lymphokines in Allergy
& Immune Diseases, DeWeck, A.L., Immun.Pract., 357:15 ; Sept.
- Specific Immunologic Unresponsiveness,
Linscott, W.D.; Basic & Clinical Immunol. 3rd Ed; Lange Med.
Pub., Palto Alto, CA, 1981
- Proceedings of the 3rd Int'l. Lymphokine
Workship; Oppenheimer, J.; Academic Press, 1983
- Interlukins & Interferons in Basic
& Clinical Immunology, G.H. Edition; Ruscotti, F.W.; Faltyner,
C.R., Appleton & Lange, Los Altos, CA 1987
- FOR TREATMENT INFORMATION OR
PROTOCOLS, PLEASE CALL DR. BORMANN'S OFFICE AT THE NUMBER BELOW
TO SET UP A CONSULTATION. EACH CASE IS MONITORED INDIVIDUALLY.
THERE ARE NO 'COOKBOOK' PROTOCOLS. IT REQUIRES AN INITIAL CYTOLOGY
SMEAR & EVALUATION PLUS INJECTION PROTOCOL, INSTRUCTION,
AND SUPPLIES. MOST OF THE TIME THIS THERAPY ONLY REQUIRES ONE
VISIT TO THE PHYSICIANS OFFICE AND IS DONE LONG DISTANCE UNDER
PRESCRIPTION AT HOME WITH VISITS AS NEEDED.
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