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"Figure 82: A schematic view of the fate of ozone in the skin during HBOEX. Ozone dissolves in the water-sebum film overlaying the outer layer of the stratum corneum and reacts immediately with PUFAs (polyunsaturated fatty acids) generating ROS (reactive oxygen species, among which H202, 0 1, etc. ) and LOPs (lipid oxidation products/ozonides). These compounds can be partly absorbed and pass through the transcutaneous barrier, facilitated by the intense vasodialation induced by the sauna. Both lymphatic and venous capillaries can rapidly transfer LOPs into the general circulation, thus inducing systemic effects. Numbers indicate: 1) The stratum corneum overlain by a superficial hydrolipid film in which ozone gas dissolves and generates ROS and LOPs. 2) Malpighi's layer. 3) The basel cell layer. 4) The dermis "

Taken from "Oxygen - Ozone Therapy, A Critical Evaluation",
Chapter 18, pg. 209.
Velio Bocci, M.D., Respiratory Specialist &Professor of General
Physiolgy, University of Sienna, Italy ©2002, Kluwer Academic
Publishing, The Netherlands