PHOTODYNAMIC THERAPY

Photonic-Therapy
Light Therapy--The Energy of God...
(also called phototherapy, photodynamic therapy, photoilluminesence, cytoluminesence, photoirridiation, etc.)

"I am the Light of the World. Whoever follows me will never walk in darkness, but will have the light of life "-- John 8:12
"The True Light that gives Light to every man ..." --John 1: 9
"God is Light...in Him there is no Darkness at all" -- I John 1:5
"He existed before all things and He holds everything together"--Col. 1:17
(Selective cellular cytotoxic effects to infected and metabolicallly derranged cells...virally infected, cancerous cells, etc.
Also used to accelerate wound healing and skin repair through collagen production response...)

DESCRIPTION: The use of specific light waves (frequencies) to create a beneficial biological response in diseased or injured tissue, alone and also through the use of light-absorping compounds which in turn produce the desired effect. (Photo sensitizers...)

In traditional medicine, it is called PDT (Photo-Dynamic Therapy). In alternative circles, it is more than just the use of specific light waves and photo-sensitizing drugs (which are toxic for the most part to the liver). There are very specific light-absorbing compounds found in the plant kingdom (from which the pharmacologists have extracted their drugs) which can be utilized orally to accomplish much the same thing, perhaps better since these compound will work synergistically with each other in their natural state, which can't be accomplished when using isolates from the drug-for-profit model. By way of background, here's some exerpts from Dr. Douglass' book "Into the Light"...Books & Literature Order Form

HISTORY: Writing in the 1800's, and known as the father of photo-active compounds, a French researcher named Tappeiner found that a variety of
parasitic and neoplastic (tumorous) conditions of the skin could be treated by applying the photo-sensitive compound eosin, and then exposing the skin to sunlight. He also noted that artificial light could be substituted for sunlight. Knott's work has taken a giant step forward with the (re)discovery that certain photo-sensitive chemicals can remarkeably increase the effectiveness of treatment of sick cells by UV light. Old German medical literature from the late 19th century reveals that diptheria toxin, tetanus toxin, and ricin (a chemical warfare toxin) are all neutralized by the combination of photosensitive drugs and light.

SOME PROPOSED MECHANISMS: "The list of chemicals and compounds that can be made photoactive is almost endless. Steroids (cortisone) has been used with great success as photoactive compounds when they're combined with diazo or azide chemical groups. These chemical groups have a high degree of intrinsic photoactivity. This activity is retained when they're incorporated into another chemical such as cortisone, which renders the entire compund photoactive. Sixteen-Diazocortisone is probably the preferred photoactive steroid because it retains a high degree of cortisone's original pharmacological activity. This photo-active cortisone, upon addition to the blood, readily enters lymphocytes, or other nucleated cells, and associates itself with the cortisone receptor sites in those cells. The cell is then photosensitized because of the diazo molecule attached to the cortisone, and will be strongly affected by exposure to UV light.

In the body, the most rapidly dividing cells (such as cancer) are more strongly affected by photon energy. These cells require cortisone to function and have cortisone receptors on their surface to "grab" what they need out of the blood. However, the modified cortisone containing the diazo chemical is grabbed just as redily. These molecules of modified cortisone both block the cell's ability to absorb normal cortisone and prevent the cell from utilizing its own cortisone. As a consequence, the receptor's ability to transmit cortisone, vital to the continued metabolic activity of the cell, is blocked. The cells quickly become unable to function because of "cortisone deficiency" and are rapidly destroyed.

It is possible to sensitize blood cells just like you would a photographic plate. There are many sensitizing substances, most of which are fluorescent, but the fluoresence is not the cause of the reaction. The photo-dynamic effects occur only in the presence of oxygen. (Hence why therapists always utilize ozone MAHT or peroxide drips with this in many alternative clinics...).

Among photo-dynamic sensitizers are erythrosin, rose bengal, rhodamine, anthracene derivatives, acridine dyes, some amino-acids, methylene blue, quinine, some sulfonamides, phenothiazine, tetracyclines, coal tar derivatives, chlorophyll, hypericin, porphyrins, and 8-MOP. The latter (eight-methoxypsoralen) is being used in research at Yale Medical School. I suspect that some of the older compounds listed above are as effective as 8-MOP, but they have no appeal to drug companies (not patentable) and therefore are not profitable.

... Phyto-cytotoxic dyes (a dye which when subjected to light, activates and becomes toxic to the cells) such as rhodamine or fluorescein. The dye will be delivered to the targeted cells, then irradiated with UV light, thus wiping out only the affected abnormal cells. Even insulin can be used to link with a photo-cytotoxic dye for delivery to a targeted cell type. These cellular "photo-cytotoxins" can revolutionize medical therapy if they are implemented on a large scale..."--excerpted with permission from Dr.Wm.Campbell Douglass Book "Into the Light".

A different explanation from one of the manufacturers of LED light units we sell...

"Photons are absorbed in cytochromes and porphyrins within the mitochondria and at the cell membrane, thus producing singlet oxygen. This causes the formation of protein gradients across cell membrane and across membrane of the mitochondria. Thus causing changes in cell membrane permeability, increased ATP levels, DNA production and increased nitric oxide levels."

Also consider Ken Dillions work on the effects on blood of photonic therapy. In his excellent book "Healing Photons" does an excellent overview of the subject also. One may go to his website and essentially see the majority of the book in print online at www.biophoton.com. He basically believes that the cells act as a type of storage battery, releasing photons continually...

DIFFERENT PHOTOTHERAPY METHODS:

1. Blood Irridiation (called UVBI, Hemo-irridiation, Photophoresis, PhotoIlluminesence, PhotoDynanic Therapy (PDT) Blood Irridiation, Biophotonic therapy, Cytoluminescent Therapy, etc.) This form involves exposing whole blood to specific bands of light waves, usually UV-B and UV-C. Use of light activated compounds like 8-MOP/Psoralens are used in medical PDT. There are several good books on the market about its uses in both traditional medicine and alternative. Check out our website info. on the UVBI procedure we've done for the last 5 years at: BIO-OXYDATIVE THERAPY PROGRAM-OZONE, UVBI, PEROXIDE, DMSO, KLENNER ASCORBIC DRIPS, ETC.

2. Tissue & Wound Irridiation: Sometimes called PhotoTherapy or PhotoDynamic Therapy (PDT) or Cytoluminescent Therapy (CLT) for Cancer... it has been used for many years in Dermatology and more recently for accelerated wound healing and for specific types of tumors. Continued research is showing great promise in a much broader application...This involves specific frequencies of light energy applied topically to tissue. This work has advanced tremendously under the research team of Dr.Whelan from the Medical College of Wisconsin. This can take the form of UV, Red LED, LLLT (low level laser therapy), etc.

CONDITIONS WHICH VARIOUS PHOTO-THERAPY METHODS HAS PROVEN BENEFICIAL FOR:

SOME TRADITIONAL MEDICAL APPLICATIONS


Photodynamic therapy (PDT) is a cancer treatment modality that recently has been applied as adjuvant therapy for brain tumors. PDT consists of intravenously injecting a photosensitizer, which preferentially accumulates in tumor cells, into a patient and then activating the photosensitizer with a light source. This results in free radical generation followed by cell death. The development of more effective light sources for PDT of brain tumors has been facilitated by applications of space light-emitting diode array technology; thus permitting deeper tumor penetration of light and use of better photosensitizers. Lutetium Texaphyrin (Lutex) and Benzoporphyrin Derivative (BPD) are new, second generation photosensitizers that can potentially imrove PDT for brain tumors. Lutex and BPD have major absorption peaks at 730 nm and 680 nm respectively, which gives them two distinct advantages. First, longer wavelengths of light penetrate brain tissue easily so that larger tumors could be treated; and second, the major absorption peaks mean that more of the drug is activated upon exposure to light. Tumoricidal effects of Lutex and BPD have been studied in vitro using canine glioma and human glioblastoma cell cultures. Using light-emitting diodes (LED) with peak emissions of 728 nm and 680 nm as a light source, a greater then 50 percent cell kill was measured in both cell lines by tumor DNA synthesis reduction. The effectiveness of Lutex and BPD against tumor cells in vitro thus established, we have taken the first step toward determining their in vivo by performing experiments to determine the largest doses of both Lutex, or BPD, and light that can be administered to dogs before toxicity is seen, i.e. the maximum tolerated dose (MTD). Using this dose allows us to effect maximum tumor cell destruction during in vivo studies. Based upon the MTD of Lutex and BPD in dogs, human trials are now underway.
For longer wavelengths of light, the improved NASA LED-technology is required. LED's are an effective alternative to lasers for PDT. Laser conversion to near-infrared wavelengths is inherently costly and inefficient, using an argon ion or KTP/YAG laser beam that is converted by a dye module, usually to 630 nm. LED's have been frequently used to emit longer wavelength broad spectrum near-infrared light of 25-30 nm bandwidths. LED lamps traditionally consist of an array of semiconducting LED chips. In recent years, improvements in semiconductor technology have substantially increased the light output of LED chips. A novel type of LED chip is based on the semiconductor Aluminum Gallium Arsenide (AlGaAs). These LED chips have been manufactured to emit light with peak wavelengths of 680 and 730 nm, which are optimal wavelengths for the absorption spectrum of the new photosensitizers used for cancer PDT.

MRI-scans of brainstem tumor (white spot lower midcenter-left) before & after PDT show significant reduction Children's Hospital of Wisconsin © 1999-01, Medical College of Wisconsin
At the Medical College of Wisconsin LED light sources are being used in a number of medical research applications. with funding from the NASA Small Business Innovative Research (SBIR) program.

MECHANISM OF ACTION OF 8-MOP PHOTO-ACTIVATED CYTOTOXIC COMPOUNDS (for use with UV light but most work with less harmful sources of light energy like that emitted from a Far Infrared Light or Full Spectrum Light Bulb...).










This graphic is courtesy of one of the companies manufacturing psoralens for traditional PDT using UV, Cerus corp. There are many other companies out there with their own psoralen-style compounds. http://www.cerus.com/pages/solution/cerussolution.html
usatoday.htm (article on Cerus' technology for cleaning the blood supply)

IMPORTANT NOTE: Each Photo Activator Compound or formula is designed to react with specific wavelengths in order for the company to maintain a patented product. There are dozens of photoactivation drugs coming onto the market. All these pharmaceutical products have side effects, particularly risk of liver damage and therefore require FDA trials and approval as a treatment compound. The Business of Medicine is very expensive...

NOTE: This discussion is for Educational Purposes Only. It is not designed to promote any specific company or device.

Non-Traditional Uses of Photo Therapy

FOR IN-HOME USE
INTRODUCTION: As an adjunctive service to Europa's Cancer Clinical Program as well as providing options to expensive Clinical Therapy programs which can run thousands of dollars per week, we have developed an in-home program as an adjuvant therapy for patients for those unable to get to the clinic due to financial or time constraints, who would be interested in utilizing it at home. NOTE: This protocol was designed by Dr.Bormann and is newer and there are no studies available on outcomes exept anecdotal. It comes out of much prayer, intuitive belief and knowledge accumulated over the years working in TJ and with patients from around the world, and discussion with various experts in physiology, radiology, physics, biochemistry, nutrition and other fields of discipline in the healing arts.

Traditional medical PDT (Photo theapy) is utilized primarily in dermatology and also in a very narrow range of other conditions currently: T-Cell Lymphoma, Psoriasis, and some research, as mentioned, for Cancer by Wisconsin School of Medicine under Dr.Whelan. It is now being widely shown for its application for Dermatology / Skin remediation in Plastic Surgery (i.e. Dr.Shamban the Dermatologist on ABC's popular series "Makeover"...). Aesthethicians and Cosmotologists are starting to use it also. Having been trained in phototherapy by one of the oldest living phototherapy physicians who used UVBI clinically (treating blood) up until the 1970's in Los Angeles for pneumonia, etc., I have a good understanding of the appropriate applications and mechanisms of action.

The primary method we've used at the TJ clinic (Europa) is UVBI (blood irridiation) but as the field continues to grow and expand, I have put together a broader application which I think will prove beneficial. The light-activator units I use are not UV units (which require a physicians prescription), and we are NOT treating blood at home (that requires skilled nursing and a physician). This is a broader application of PhotoDynamic Therapy which seems to have distinct advantages through the research NASA has provided, that UV Light is not necessary to achieve the benefits of PDT because many sources of light can activate these compounds, if in fact that turns out to be the mechanism by which benefit is achieved (which we're still not sure of yet)...I make no promises of cures of anything, however I truely believe that together with a good nutritional and exercize program and pure water, prayer and positive attitude, perhaps some frequency therapy, that optimal benefits can be achieved.

DIY Phototherapy
For specific application questions, call our office.

References
http://info.med.yale.edu/dermatology/html/faculty/edelson.htm
http://www.mcw.edu/whelan/
Clark, Sir Arthur, Beyond Gravity, National Geographic Jan. 7, 2001, p2-29. Reports that Dr. Harry T. Whelan of the University of Wisconsin Medical School has successfully treated wounds, third degree burns, and brain cancer with LEDs.
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Drollette, Dan, Can Light Hasten Healing in Space? Biophotonics International Sept/Oct 2000, 46-49.
Enwemeka, CS, et al., Biomechanical effects of three different periods of GaAs laser photo stimulation on tenotomized tendons, Laser Therapy 1994;6:181-188.
Enwemeka PhD, Chukuka S, Assistant Professor of Physical Therapy - U. of Texas, Health Science Centre, San Antonio, TX Laser Biostimulation of Healing Wounds: Specific Effects and Mechanisms of Action; The Journal of Orthopaedic & Sports Physical Therapy, Vol. 9. No.10, 1988
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Marshall Space Flight Centre press release 00-336 (12-18-00). http://www.msfc.nasa.gov/. Describes how LEDs are being used to heal hard to heal wounds such as diabetic skin ulcers, serious burns, oral sores, and musculoskeletal training injuries.
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