Retine-C Complex Methylglyoxal Formula



RETINE-C Complex™ Concentrate
Methylglyoxal-Ascorbate Complex Formula
Based on Original Dr. Albert Szent-Gyorgi & Koch Research
BIO-IDENTICAL TO HUMAN Methylglyoxal
100% Naturally Derived from Advanced Technology & Stabilized for Maximum Activity




Dr. Albert Szent-Gyorgyi was the Hungarian Nobel Laureate in Medicine in 1937 for the isolation and discovery of Vitamin C. He also discovered iso-flavones and vitamin P. He also researched the regulatory processes of cell growth, and the regulation of cancer. He was at the Institute for Muscle Research in Woods Hole, Massachusetts.

RETINE WAS IDENTIFIED BY NOBEL PRIZE WINNER DR.SZENT-GYORGYI IN THE 1960s . . .
RETINE (METHYLGLYOXAL) STOPS METABOLICALLY ERRANT CELLS BY BLOCKING AN ENZYME NEEDED BY THESE CELLS TO MAKE ATP FROM GLUCOSE, STARVING THEM SO THEY DIE NATURALLY (Apoptosis).

In 1963 the prestigious magazine "Science" published a remarkable article about his research. In it Dr. Szent-Gyorgyi identified two substances, one called Retine, which inhibited cancer growth, and the other called Promine, which promoted cell growth and made cancerous cells grow faster. These compounds are Ketoaldehydes and are found in the body naturally as a byproduct of the Krebs Cycle and the Glyoxylase System. His research using mice achieved shrinkage of tumors by increasing the ratio of Retine to Promine with daily injections of Retine. There were no harmful or toxic side effects.

Dr.Szent-Gyorgyi explained that he and "Dr. Egyud have found that retine (methylglyoxal) stops the growth of cancer cells without poisoning other cells. When retine is present in sufficient concentration, no cell division can occur while vital cellular processes go on unhindered." The article goes on, "And what is a good bit of luck, and not my cleverness, the white-haired scientist pointed out, "is that if a cancer cell cannot grow, it dies by itself.' According to the researchers, Retine is normally produced by the body and, when it is, it prevents the growth of existing cancer cells. But the body can lose its ability to produce this substance..."Putting the retine back in the body, just as we put insulin back into a diabetic's body, can stop the growth of cancer... The scientists at Woods Hole found that cancer cells are much more sensitive to retine than normal ones, and so cancer cells may be inhibited specifically."

Before the AAAS (American Academy of Science), April 24, 1967 he announced his work results with Methylglyoxal. He stated "We along with Dr.L. Egyud, synthesized a number of methylglyoxal derivatives...The cardinal question thus was: do tissues contain glyoxal derivatives? ... The answer was YES. "To sum up, our experiments indicate that ketone aldehydes are normal constituents of tissues and have a high biological activity. THE CHEMICAL SIGNAL WHICH REGULATES CELL DIVISION MAY THUS BE A KETONE ALDEHYDE (Methylglyoxal). These glyoxal derivates, together with the enzymes responsible for their formation and deletion, form a complex system with complex equilibria, the disturbance of which may be connected with cancer"
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RETINE is the name Szent-Gyorgyi gave Ketoaldehydes, Methylglyoxal, Glyoxal, etc.
Carbonyl's like Ketoaldehyde/Methylglyoxal arrest cell division and make cells return to a normal resting state. If Carbonyl is missing, uncontrolled proliferation goes on, and cells grow wildly and uncontrollably which leads to cancer. Glyoxal & Methylglyoxal are a non-toxic substance that is naturally found in human biochemistry. Restoring depleted levels has significant metabolic balancing effects.

MECHANISM OF ACTION DISCOVERED BY DR.MANJU RAY, et.al : ENZYME INHIBITOR
We now know from on-going research that it is an enzyme which is blocked denying access of cancer to glucose to make ATP. The enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) is required by cancer cells and cells using glucose for energy to produce ATP. Methylglyoxal blocks this enzyme's action and without energy, the errant cells die. The cool thing is that it doesn't affect normal cells since they don't use just sugar for energy like cancer cells do. Other researchers in Europe have done research (over 200 published studies now and climbing) on this biochemistry...

DR. WILLIAM KOCH, M.D., Carbonyl Group Pioneer of the early 20th Century.
Homeopathic Carbonyl Group Catalysts of Glyoxal & Methylglyoxal
Well known Nobel Prize winner and contemporary of Dr.Szent-Gyorgyi, Dr. William Koch, worked on this same issue with a different approach. Dr. Szent-Gyorgyi acknowledged his work saying, "A decade ago, a very intuitive researcher, Dr. William F. Koch, came to the same conclusion about the possible importance of Carbonyls in regulation of cell division and carcinostasis." Koch's work was in the earlier part of the 20th Century, 1910s-1950s. He was a classical homeopathic physician and worked at U of Michigan.

Dr. Koch and Dr. Szent-Gyorgyi took different approaches to supplying methylglyoxal to the body. Dr. Szent-Gyorgyi developed a way to supplement larger quantities of methylglyoxal as a food or vitamin. Koch, being a homeopathic doctor, preferred to make it homeopathically to stimulate the body's own production. Both methods work but used together may be ideal.
Koch Methylglyoxal Homeopathic Catalysts
Made in the USA !

NEW RETINE-C COMPLEX™ CONCENTRATE -- Technology Breakthrough Produces a Highly Active, Biologically Available & Stable Methylglyoxal + Vitamin C Complex for the first time ever...

Advances in organic and biomolecular chemistry have yielded some incredible new products to help maintain health and this is one of them. Our chemist has been able to use advanced technologies to successfully produce a toxin-free Stabilized Methylglyoxal compound bound together with L-Ascorbate (buffered C) to yield a very active stable compound. Traditionally methylglyoxal has been available alone and one had to take Vitamin C supplements with it. With the new technology, is no longer necessary since it is bound right into it. It actually is a catalyzed complex which is very active. A low strength Multi-B vitamin needs to be taken twice daily to enhance Liver detox antioxidant enzymes. We also recommend several times a week for at least 10 min. to do some mild exercise like Oxycize (Oxycize.com) or to breath 100% pure oxygen at a very low flow while gently moving vertically on a rebounder like trampoline (EWOT) in order to increase tissue oxygenation & lymphatic movement which will enhance uptake by the cells of the product and and facilitate detox of dead cellular debris. If exercise is impossible, then a good massage several times a week to move the lymph.

QUESTIONS & ANSWERS :

What Makes Your Product Unique ?
1. Ours is a pure concentrate combined with Vitamin C as a complex. It is not plain old methylglyoxal. It is not a powder or homeopathic vial. The manufacture is controlled from raw material analysis & procurement to the finished product all done here in the USA using gleaming all glass equipment in a GMP Laboratory by our Organic Medicinal Chemists.
2. All raw materials are nature identical and are the highest GMP quality.
3. Our methylglyoxal complex is made in highly controlled environment in small batches. The manufacturing technology yields absolutely pure methylglyoxal with no toxic contaminants or polymers commonly found in commerical products. Color is an indication of purity. Very pale yellow is purest. Anything darker contains toxic byproducts and polymers. We certify it free of polymers, formaldehyde, ethyl alcohol, pyruvate, lactate, formate.
4. Our product is a Bio-Identical molecularly to human methylglyoxal, which declines naturally with age. It is highly bioavailable and has shown no toxicity.
5. Our patent-pending product is the ONLY product worldwide which is stabilized and complexed with L-Ascorbate molecule to retain its highly active state.
6. It is not a Homeopathic like Koch made in vials for injection or oral use. It is the purest form of methylglyoxal complexed with Vitamin C.
Are There Any Side Effects?
The only side effect we've seen sometimes is if the liver is stressed from alcohol, hepatitis, tylenol, pain meds, antifungal drugs, chemo, radiation, etc., the rapid die-off and apoptosis can cause nausea and vomiting. We recommend letting the liver stabilize a few weeks first prior to taking. It cannot be taken simultaneously with Chemo or Radiation or Opiate Pain Meds like Valuim or Morophine or similar drugs.
What Does it Consist of?
Retine-C™ is a Liquid. It is a light golden color with a sight fizz and tartness. It is very mild and blends into any drink (except milk) or may be taken alone in water. Remember it is a normal constituent of the body. Some researchers using a non-modified off-the-shelf chemical form which contained toxic byproducts (which is NOT our product) found kidney damage in mice...See Toxicity Issues discussion below. On-going clinical research shows that inside the human body (in-vivo) toxicity is not an issue at all.
What Kind of Results Are You Getting ?
Early results are encouraging with several in remission but we have no studies to date. Results vary. THIS IS NOT A MAGIC BULLET BUT SHOULD BE USED AS AN OVER ALL ADJUNCTIVE PRODUCT WITH WHATEVER YOUR ALTMED PHYSICIAN HAS YOU ON.
Why Haven't I Heard Of It?
Retine-C™ Methylglyoxal Complex is a new product, never before available in the world. Because of it's nature, we will not mass-market it. Mainstream Medicine cannot use or promote it so discussing it with your oncology team is beyond useless since they're not trained in the use of natural remedies and cannot use natural remedies for cancer since it violates their scope of practice for their license. Some more open minded oncologists may be interested and allow its use but generally they're unfamiliar and would criticize it or even demand you don't take it. Alternative Medical arena is where you'd find support for it most likely. This is a highly specialized product with a niche market. We don't advertise but only have our websites and word of mouth and its use by a very small group of qualified practitioners and pharmacists. We hope to offer a list of qualified AltMed practioners for those who need a referral.
Why is Availability so Limited?
First of all, it is manufactured by a small commercial labratory and not some huge commercial lab with large budgets. There is very limited distribution at this point. It is self-funded and proceeds are plowed right back into more manufacturing. We're looking for private investors who we believe are not just profit driven in order to grow but it has been hard going with the economic challenges these days.
Where is it Available to Purchase ?
This is a highly specialized item manufactured by one Chemist in the world. It is not widely distributed currently. We're a direct authorized manufacturer's rep. It will NOT be sold to health food stores or MLMs or retailers. We have a few physicians and pharmacists as qualified professionals we have allowed to buy it for their patients since users need to be monitored if they are dealing with serious conditions. It is sold as a nutritional supplement to replenish the body's methylglyoxal stores, it is NOT a drug. It has not been reviewed by the FDA. AT THIS TIME IT IS NOT AVAILABLE FOR INTERNATIONAL CUSTOMERS EXCEPT CANADA, BECAUSE OF THE REFRIGERATION ISSUE AND THE EXHORBINANT COST OF INTERNATIONAL REFRIGERATION.
I'm A Qualified Medical Practioner or Pharmacist. Can I Buy It For Resale to My Patients / Customers ?
Yes. We're looking for qualified resellers. There is a case lot minimum order of 12 bottles. Call our office to discuss it with Dr.Bormann. We'll send you an application and price sheet.
How Long Does One Need to Take It ?
It depends on the person. Some use it adjunctively as a foundational therapy to go with the other things they're using. It takes 90 days for new cells to appear and to evaluate the effectiveness of any protocol or new product, therefore we recommend using it for 3 mos. minimum. A single bottle is not enough to usually see any significant change. This is something to add to one's regimen for the long haul. It is not something to casually try once and abandon.
What about toxicity ?
There are over 200 research articles published over the years on this substance. Methylglyoxal as a chemical is available in a commercial chemical form from a few chemical companies for commercial uses, etc. COMMERCIAL METHYLGLYOXAL SHOULD NEVER BE INGESTED BECAUSE OF THE TOXIC POLYMERS AND OTHER CHEMICAL BYPRODUCTS. Commercial Methylglyoxal contains known carcinogens such as formaldehyde, ethyl alcohol, pyruvate, lactate, formate and polymers. In fact, the amount of formaldehyde can account sometimes for as much of 30% of these over the counter Methylglyoxal solutions ! WE USE ABSOLUTELY NO COMMERCIAL CHEMICAL METHYLGLYOXAL IN OUR PRODUCT. Ours is made from scratch directly through highly controlled organic chemical processes in a GMP Laboratory IN THE USA. Our product is certified free of any toxic chemical byproducts or polymers. The patent pending process is the result of 3 years of concentrated research to develop a cost effective minimally processed product WHICH PRODUCES A BIOIDENTICAL MOLECULE, AND WHICH IS STABILIZED TO RETAIN IT'S ACTIVITY.
Is it Expensive?
We are currently selling it for $185.00 per 960 ml bottle,which is a one-month supply. Our labs manufacturing costs are going up but we're holding the cost down so as many people as possible can afford it. Other MG products range from $200-$300 or as powdered mix for around $195 which is a weak precursor w/ fillers and does NOT have vitamin C bound to it. We're a direct authorized Rep. for the Manufacturing Chemist.
Return Policy:
Due to the specialized nature of this product, all sales are final. There are absolutely no returns or refunds. We will exchange bottles verified damaged in shipping and returned immediately w/photo if the customer calls us to notify us so we can put in a loss claim with the carrier. Bottles which have not been kept refrigerated or are damaged by the customer from misuse will not be eligible for return.
Special Express Shipping Required Due to Mandatory Refrigeration:
Because we need to keep the product refrigerated to maintain stability, we will only ship in insulated container with ice packs Express Mail or FEDEX Express with Signature Required since it is crucial the product be refrigerated immediately to insure it's activity. This is more expensive and we apologize but this is the requirement of our chemist. Cost for this type of shipping service will vary depending on the carrier. In Winter we can sometimes ship Priority Mail w/Signature to some cities, but otherwise it must be Express Shipping.
International Orders:
Because of the refrigerated shipping requirements, WE DO NOT SHIP INTERNATIONALLY EXCEPT TO PARTS OF CANADA.


RECENT RESEARCH & CLINICAL STUDIES




There has been encouraging work done in Calcutta, India by Prof. Manju Ray (photo at left) who continues to do on-going research. She recently published a study with terminal cancer patients in which the overall results were quite encouraging. (Note: this is on end-stage patients who had undergone chemotherapy, surgery, radiation, etc.) The formula Dr.Ray used is not the same as ours but much simpler. We continue to follow her work and stay in contact via email periodically.
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USES:

Cancer Therapy & Chronic Infection (Fungal or Bacterial) Adjunctive use under qualified physician monitoring

Anti-viral / Immune Therapy (Koch used it as an antiviral therapy in homeopathic form)

Anti-fungal & Anti-bacterial since these microbes use sugar for food and MG starves them of food, leaving healthy normal cells unaffected

Pain management (Analgesic)

Helps Reduce Blood Pressure (Hypotensive)


Retine-C Complex Concentrate is Highly Active & Bioavailable
It is a Stabilized Complex, the first of its kind in the world
Made from scratch with Advanced Fermentative Technology in High Controlled GMP Lab in the USA.
Organic Plant Sourced
Bio-Identical to Human MG
Helps maintain homeostasis by Replenishing Retine / Methylglyoxal levels which decline with age
Absolutely NO toxic contaminants, additives, etc.
Requires 40ºF to stay stable. Refrigeration is Required

SUPPLEMENT FACTS
Size: 960 ml. Retine-C Concentrate
Serving Size: 8 ml.(1.25 tsp)
# Servings per Bottle: 120, a 30 day supply
Contains: Proprietary mix of Distilled Water, Retine-C Complex Concentrate. Each serving provides 480 mg. of L-Ascorbate form of Vitamin C.
Certified Free of Pyruvates, Formaldehydes, Ethyl alcohol, Lactate, Formate
No added preservatives or allergens like soy, glutens, corn, dairy, etc.
A slight fizz and tartness is normal on opening.

USE INSTRUCTIONS: Based on Dr. Ray's clinical protocol. Take 8 ml.( 1.5 tsp) in 2 oz. water or juice 4 times daily. in 2 oz. water 4 times daily (effective dose is 30 mg./ kilo body weight. i.e.150 lb. person = 68 kilos x 30mg/k = 2040 mg./day. Always take with food. Taking it consistently is important. Take 5 days on, 2 off. Critical to take a low strength food based multi-B vitamin twice daily to provide added antioxidant protection for liver function and to help facilitate detoxification pathways for cellular debris.

IMPORTANT NOTE: To Reduce Liver Stress as it detoxifies cellular debris, we recommend eating absolutely no animal protein products or high fat meals for at least 10 days if on any RX drugs which damage the liver like antifungals, chemo, etc.. After that, small amounts of high quality yogurt, free range organic eggs, chicken, turkey, fish are OK. Stay away from red meats and cured foods with nitrates and ALL SOY products, Antifungal drugs or Tylenol®.

REFRIGERATE IMMEDIATELY AND KEEP LIGHT FREE. (Vitamin C is deactivated by Light) Wrapping with foil can protect it further from light.

CAUTION: Not for use by Pregnant Women, Type I Diabetics. Individuals with serious conditions should use under qualified physician monitoring. Keep Away from Children. Discontinue if adverse effects occur.

Mandatory FDA Disclaimer: The statements & products shown on this website have not been evaluated by the US Food and Drug Administration. Statements are not intended to constitute professional advice for treatment of any disease but are for educational purposes. These products are not intended to diagnose, treat, cure or prevent any disease.

THIS IS ONLY AVAILABLE TO PERSONS WHO CALL OUR OFFICE FIRST TO SPEAK WITH DR.BORMANN TO SEE IF IT IS APPROPRIATE.

Packaging: Specially Manufactured Brown Plastic 960 cc PET Light Protective Bottles
Price per bottle: $185.00 ea. + S & H. Shipping via Express Mail generally runs around $55-65. FEDEX Next Day is available but is much more expensive.

WE DO NOT ACCEPT MULTIPLE BOTTLE ORDERS ON FIRST TIME USE. Once the person is confirmed they're doing well with it, then we will accept multiple bottle orders.

SHIPPING: We only ship it Insured Express Mail or other Express method since it requires refrigeration or to stay cold. Due to the delicate hand -made high quality manufacturing methods in small batches, combined with the fact that it has a 3-6 mo. shelf life, we sometimes run out. We'll notify you if we're backordered. All orders are prepaid. This is a special order item.

ABSOLUTELY NO INTERNATIONAL ORDERS CAN BE ACCEPTED EXCEPT SOME PARTS OF CANADA.

SPECIAL PACKING & SHIPPING REQUIRED. WE USE ICE PACKS IN INSULATED COLD PAK BOXES .

SHIPPING IS OVERNIGHT, INSURED (Depending on courier, "overnight" rarely means overnight these days. Even guaranteed overnight isn't always possible but generally 1-2 business days for most parts of the US).

THE PRODUCT MUST STAY REFRIGERATED.
ALL SALES FINAL. NO RETURNS OR REFUNDS. EXCHANGE ONLY FOR VERIFIED SHIPPING DAMAGE.

Research Citations & Abstracts on Methylglyoxal / Retine
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Cancerostatic Action of Methylglyoxal; Science 7 June 1968: Vol. 160. no. 3832, p. 1140
DOI: 10.1126/science.160.3832.1140
Laszlo G. Együud and Albert Szent-Györgyi
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http://www.jstor.org/pss/67257
The Living State and Cancer
Albert Szent-Gyorgyi, Ph.D.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 7 (Jul., 1977), pp. 2844-2847
Published by: National Academy of Sciences
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PUBMED Listing of Szent-Gyorgyi's research publications. Several on Retine & Methylglyoxal
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=Szent-Gyorgyi A[au]&dispmax=50
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National Library of Medicine Szent-Gyorgyi Papers
national.html
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Chemical Nature of Free Retine, an Anti-tumour Agent; Nature 209, 1346 - 1347 (26 March 1966); doi:10.1038/2091346b0
CLAUDE MARMASSE
9, Quai de l'Abbé Grégoire, Blois, France.
THE wide distribution of natural anti-tumour agents has been shown by Szent-Györgyi et al. 1 and many others. There is, notably, such a compound in human urine, which has been called retine and has been previously isolated by Hegyeli et al. 2. This compound has a molecular weight of approximately 430 (ref. 3) and induces a significant regression of Krebs-2 carcinoma in Swiss albino mice. Treatment of retine with hot acetic acid releases a compound which is responsible for the anti-tumour activity 4.
1. Szent-Györgyi, A. , Hegyeli, A. , and McLaughlin, J. , Proc. U.S. Nat. Acad. Sci., 49, 878 (1963). 2. Hegyeli, A. , McLaughlin, J. , and Szent-Györgyi, A. , Science, 142, 1571 (1963). | PubMed | ISI | ChemPort | 3. Marmasse, C. , Hegyeli, A. , and King, A. (to be published). 4. Hegyeli, A. (personal communication). 5. Jaffe, H. , and Orchin, M. , Theory and Application of Ultraviolet Spectroscopy (Wiley, New York, 1962). 6. Karrer, P. , Organic Chemistry, fifth English ed. (Elsevier, Amsterdam, 1950). 7. Dashkevich, L. , and Sirraya, V. , Zh. Obshch. Khim., 32, 2330 (1962). (See Chem. Abs., 58, 7946; 1963.) | ISI | ChemPort | 8. Krepelka, J. , and Vebersik, V. , Chem. Listy, 43, 25 (1949). (See Chem. Abs., 44, 9565; 1950.) | ISI | ChemPort |
Treatment of a number of cancer patients suffering from different types of malignancies by methylglyoxal-based formulation: A promising result; Cancer Therapy Vol 4, pp. 205-222, (2006)
Dipa talukdar, Subhankar Ray, Sanjoy Das, Ashok Kumar Jain, Arvind Kulkarni, Manju Ray
Dept. of Biochemical Chemistry, Indian Association for Cultivation of Science, Jadavpur, Calcutta, India. SVS Marwari Hospital, Calcutta, Lokmanya Medical Research Centre, Chinchwad, Pune India
"Abstract : Based on our previous in vitro studies with human cells and in vivo studies with animals we had developed an anticancer formulation with methylglyoxal as the lead ingredient. This formulation has a tumoricidal effect by inhibiting specifically in cancerous cells the electron flow and the transfer of reducing equivalent necessary for the production of adenosine-5¢ -triphosphate, the cellular energy currency. By keeping this remarkable property in mind, we had treated 24 patients suffering from different types of malignancy (mostly in very advanced stage of the disease) with this methylglyoxal-based formulation. The results indicate a dramatic positive effect on the patients. Out of the 24 patients, 11 are in excellent physical condition, the condition of 5 patients can be considered stable. The rest had either opted out from the treatment or died during the course of the study. These results strongly suggest that this formulation is by far more superior than other present forms of treatment against cancer. It is imperative that this formulation be widely used in treating cancer patients, as well as to attempt the improvement of its efficacy. "

Does excessive adenosine 5'-triphosphate formation in cells lead to malignancy? A hypothesis on cancer. Med Hypotheses. 1997 Jun;48(6):473-6. Related Articles, Links
Ray S, Ray M., Department of Biochemistry, University College of Science, University of Calcutta, India.
In biological systems, adenosine triphosphate (ATP) is the principal contributor of free energy necessary for anabolic reactions and is also a precursor of nucleic acids. Moreover, active transport of metabolites into cells is also driven by hydrolysis of ATP. So, a cell may grow, multiply and ultimately turn malignant when it has been transformed in such a manner that it produces excess ATP as compared with its usual metabolic demand. Recent studies have indicated that mitochondrial complex I and the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) may be critically altered specifically in malignant cells. So, we further propose that this excessive ATP formation may be due to altered mitochondrial complex I and GA3PD of malignant cells.
PMID: 9247887 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9247887

Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal.
Biswas S, Ray M, Misra S, Dutta DP, Ray S.
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta 700 032, India.
The effect of methylglyoxal on the oxygen consumption of mitochondria of both normal and leukaemic leucocytes was tested by using different respiratory substrates and complex specific artificial electron donors and inhibitors. The results indicate that methylglyoxal strongly inhibits mitochondrial respiration in leukaemic leucocytes, whereas, at a much higher concentration, methylglyoxal fails to inhibit mitochondrial respiration in normal leucocytes. Methylglyoxal strongly inhibits ADP-stimulated alpha-oxoglutarate and malate plus NAD+-dependent respiration, whereas, at a higher concentration, methylglyoxal fails to inhibit succinate and alpha-glycerophosphate-dependent respiration. Methylglyoxal also fails to inhibit respiration which is initiated by duroquinone and cannot inhibit oxygen consumption when the N,N,N', N'-tetramethyl-p-phenylenediamine by-pass is used. NADH oxidation by sub-mitochondrial particles of leukaemic leucocytes is also inhibited by methylglyoxal. Lactaldehyde, a catabolite of methylglyoxal, can exert a protective effect on the inhibition of leukaemic leucocyte mitochondrial respiration by methylglyoxal. Methylglyoxal also inhibits l-lactic acid formation by intact leukaemic leucocytes and critically reduces the ATP level of these cells, whereas methylglyoxal has no effect on normal leucocytes. We conclude that methylglyoxal inhibits glycolysis and the electron flow through mitochondrial complex I of leukaemic leucocytes. This is strikingly similar to our previous studies on mitochondrial respiration, glycolysis and ATP levels in Ehrlich ascites carcinoma cells [Ray, Dutta, Halder and Ray (1994) Biochem. J. 303, 69-72; Halder, Ray and Ray (1993) Int. J. Cancer 54, 443-449], which strongly suggests that the inhibition of electron flow through complex I of the mitochondrial respiratory chain and inhibition of glycolysis by methylglyoxal may be common characteristics of all malignant cells.
Biochem J. 1997 Apr 15;323 ( Pt 2):343-8. Related Articles, Links
Similar nature of inhibition of mitochondrial respiration of heart tissue and malignant cells by methylglyoxal. A vital clue to understand the biochemical basis of malignancy. Ray S, Biswas S, Ray M.; Mol Cell Biochem. 1997 Jun;171(1-2):95-103.
Department of Biochemistry, University College of Science, University of Calcutta, India.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9201701

Implication of bioelectronic principle in cancer therapy : treatment of cancer patients by methylglyoxal - based formulation. Manju Ray, Swapna Ghosh, Manoj Kar, Santajit Datta, Subhankar Ray Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta 700 032, India.
(2001) Indian Journal of Physics, 75B. No2, 73-77

Effects of methylglyoxal on platelet hydrogen peroxide accumulation, aggregation and release reaction. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8640957
Leoncini G, Poggi M.
Istituto Policattedra di Chimica Biologica, Universita di Genova, Italy
Cell Biochem Funct. 1996 Jun;14(2):89-95. Related Articles, Links
Mol Cell Biochem. 1997 Dec;177(1-2):21-6. Calcutta.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9450641
Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal.Ray M, Basu N, Ray S.
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur,

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(909) 338-3533 / FAX (909) 338-3743
E-mail: dbormann@arrowheadhealthworks.com *ARROWHEADHEALTHWORKS.COM

** Mandatory FDA Disclaimer: The statements & products shown on this website have not been evaluated by the US Food and Drug Administration. Statements are not intended to constitute professional advice for treatment of any disease but are for educational purposes. These products are not intended to diagnose, treat, cure or prevent any disease. **