- Dr.Nieper's Lithium
- Elemental Lithium
Bond to Orotic Acid (vitamin B13)
- Patented &
Manufactured by the Nieper Licensed Formulary in the USA
- NOTE: BIPOLAR PATIENTS,
THIS IS NOT THE SAME AS PRESCRIPTION LITHIUM SUCCINATE
OR SULPHATE WHICH ARE DOSED MUCH HIGHER AND ARE TOXIC TO THE
KIDNEYS AND REQUIRE PHYSICIAN MONITORING. THIS IS A LOW-STRENGTH
TARGETED NATURAL FORMULA AND IS NOT REGULATED AS A DRUG.
- Books by Dr.Hans Nieper,
- --RARE & OUT OF PRINT--
Available from us at a reasonable
price since we're an authorized trained Nieper affiliate.
- LITHIUM OROTATE
- Supplement Facts
- Serving Size: 1 tablet
- No. Servings: 100 tablets
- Each nano-vortex enterically
coated particles and tablet contains
- Per Serving
- Tablet size: 120 mg. (NOT
120 mg. of Lithium O.)
- Active Ingredient per Tablet:
4.6 mg. of Elemental Lithium salts per tablet.
- Bound to Orotic Acid (B13)
& timed released tableting agents
- Other Ingredients: Duratex,
Pure Food Glaze, Plasdone, Ac-Di-Sol, Mag. Stearate, Compritol
and Avicel. (enteric coating agents; tableting agents, timed
release agents). Each particle is enteric coated & the tablet
is also enteric coated for release in sm.intestine only.
- Ý = no dietary value
- % DV
- Use Instructions:
- 1 tab 2-3 times per day between meals.
- Note: Individuals who are using antidepressants
should be advised that receptors will be blocked and it may take
higher doses for awhile (2-3 tablets several times per day) to
achieve desired effects. Then reduce to maintenance dose. It
is not recommended in acute unstable bipolar disorder to discontinue
prescription medications without the assistance of a qualified
physician who uses nutrition and orthomolecular therapies.
- Cautions: Lithium is a natural diuretic and
so be sure to drink plenty of water. Non-Orotate
forms of Lithium should not be used by individuals with significant
renal or cardiovascular diseases, severe debilitation or dehydration,
or sodium depletion, and by individuals who are taking diuretics
or ACE inhibitors. Consult your doctor before use if you are
taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic
drugs or insulin or thyroid. Lithium should not be used by pregnant
women and breast-feeding mothers. Keep away from children.
- BIPOLAR INDIVIDUALS ON LITHIUM
CARBONATE SHOULD NOT DISCONTINUE USE OF THEIR MEDICATIONS WITHOUT
THE INVOLVEMENT OF A KNOWLEDGEABLE PHYSICIAN TRAINED IN THE USE
OF LITHIUM OROTATE.
- Packaging & Sizes
- 100 tablets $12.50
- 200 tablets $21.50
- 3 Pack $59.95
- Notes: General
rule of thumb for those using benzodiazapines and other antidepressants:
most do not realize that the drugs themselves can cause the
symptoms of depression and even suicide ! Natural alternative
minerals are a much better choice once the patient is stable.
Working with a psyciatrist/MD who deals with depression and use
applied clinical nutrition in their practices is critical to
a good transition...We recommend Dr. Hyla Cass in Pacific Palisades,
CA. Also evaluation for heavy metal & dental toxicity is
highly recommended. See the book "The Roots of Disease"
by Stephen Levy, M.D. & Robert Kulacz, D.D.S. for more information.
Also severe Magnesium deficiencies can manifest in mood and emotional
disorders, even schitzophrenia. Check out Dr.Carol Dean's book
"The Miracle of Magnesium" for more information. Oral
Magnesium frequently is not enough to affect acute conditions.
IV, oral and topical is needed.
- Lithium Orotate is targeted to the mitrochondria
and only functions there. As a result, it does not show up
in blood tests. Orotate forms of lithium are approximately
20 fold more effective than toxic synthetic lithium. If trying
to use the natural Lithium to replace synthetic Lithium carbonate
or sulphate, take approx double or triple the suggested dosing.
So 1-2 tabs 3 or 4 times per day until stabile and then back
down to whatever is necessary to maintain metabolic equilibrium.
Maintenance is usually 1 cap twice daily.
- Benefits: Lithium
is one of the minerals used by the brain to balance brain functions.
Many doctors use compound forms of Lithium for treating various
kinds of brain dysfunction problems. Different compound formulas
of Lithium have many different effects on the brain, but the
majority of harmful effects are due to the compound formula itself,
and not to the actual Lithium. Lithium in the elemental form
has never been shown to have major side effects.
- Lithium, when combined with germanium, greatly
aids the electrical transfer within the brain itself. Lithium
should be used in conjunction with magnesium. Magnesium aids
in the electrical transfer that the Lithium causes to happen.
- Uses of Natural Lithium Orotate As Described by Dr.Nieper
- BRAIN DAMAGE (Cerebral Palsey,
Autism, Stroke, TIA,Vaccine Injury, Tymerisol (methylmercury),
Chemical or Environmental Injury)*
- ASCITES / FLUID COLLECTION
IN ABDOMEN OR LUNGS
- AUTISM & AUTISM SPECTRUM
- COMBINED W/CALCIUM OROTATE,
EXCELLENT FOR HEPATTIS AND LIVER DISEASE*
- MANIC DEPRESSION / BIPOLAR
- GENERAL DEPRESSION AND ANY
MOOD DISORDER INCLUDING HORMONE OR CHEMICAL IMBALANCE*
- BRAIN ALLERGY*
- MIGRAINE HEADACHES (Lithium
reduces intracellular edema)*
- CLUSTER HEADACHES*
- CHILDHOOD EPILEPSY*
- HYPERTHYROID / GOITER*
- DRUG & ALCOHOL RECOVERY*
- BRAIN INJURIES
We only use Dr.Han's Neiper Lithium formulations
which are non toxic and do not require blood test monitoring by
a physician to prevent kidney damage by the pharmaceutical formulas
LITHIUM PROTECTS FROM BRAIN DAMAGE FROM ENVIRONMENTAL
TOXINS Lancet Reports Wayne State University in Detroit found
that lithium has the ability to both protect and renew brain
cells.(1) Nonaka, S., C.J. Hough, and D. Chuang. 1998. Chronic
lithium treatment robustly protects neurons in the central nervous
system against excitotoxicity by inhibiting N-methyl-D-aspartate
receptor-mediated calcium influx. Proceedings of the National
Academy of Sciences 95(March 3):2641.
LITHIUM INCREASES GREY BRAIN MATTER (reversing
brain atrophy). 8 out of 10 who took lithium showd an average
of 3 percent increase in brain grey matter in just 4 weeks http://www.med.wayne.edu/press/2000/press36.htm
LITHIUM ENHANCES NERVE CELL DNA REPLICATION.
DNA replication is the first step in cellular formation of any
LITHIUM BLOCKS DEVELOPMENT AND ADVANCEMENT
OF ALZHEIMERS May 22, 2003: Lithium Blocks Alzheimer Pathology
http://www.alz.org/WhatsNew/052203lithium.htm (Alzheimer's Assoc.
LITHIUN INHIBITS OVERACTIVATION OF A BRAIN
PROTEIN called the "tau" protein wich contributes to
degeneration Alzheimer's. http://www.jneurochem.org/cgi/content/abstract/73/5/2073
LITHIUM INHIBITS NEUROFIBRILLARY TANGLES,
another degenerative cause in Alzheimer's http://www.nimh.nih.gov/events/prlithium.cfm
- BENEFITS FROM PROPER LITHIUM THERAPY
- Lithium Orotate
The Unique, Safe Mineral with Multiple Uses
- by Ward Dean, M.D. and Jim
- July 1999
Lithium is a mineral with a cloudy reputation.
It is an alkali metal in the same family as sodium, potassium
and other elements. Although lithium is highly effective in the
treatment of manic depressive illness (X4 DI), its pharmaceutical
(prescription) versions, lithium carbonate and lithium citrate,
must be used with caution. The reason for the caution with prescription
lithium (RX) is because lithium in these forms is poorly absorbed
by the cells of the body - and it is within the cells that lithium's
therapeutic effects take place. Lithium ions are believed to
act only at particular sites on the membranes of intracellular
structures like mitochondria and lysosomes.
- Consequently, because of this poor intracellular
transport, high dosages of pharmaceutical forms of lithium must
be taken in order to obtain a satisfactory therapeutic effect.
Unfortunately, these therapeutic dosages cause blood levels to
be so high that they border on toxic levels. Consequently, patients
taking prescription lithium must be closely monitored for toxic
blood levels. Serum lithium and serum creatinine levels of prescription
lithium-treated patients should be monitored every 3-6 months.
- Toxic effects of RX lithium may include hand
tremors, frequent urination, thirst, nausea, and vomiting. Even
higher doses may cause drowsiness, muscular weakness, poor coordination,
ringing in the ears, blurred vision, and other symptoms.
- There has been concern that long-term RX
lithium treatment may damage kidney function, but data in this
regard are equivocal. Renal insufficiency without a known cause
has occurred in the general population, and the incidence of
renal failure among manic-depressive patients not treated with
lithium remains unknown.
- Most patients treated with RX lithium are
also taking other medications, and it is just as likely that
the few known cases of renal failure in patients taking lithium
were due to other medications that they were simultaneously taking.2-5
- Nevertheless, with potential side effects
like this, why in the world would anyone want to take lithium?
It is because lithium has been found to be one of the most effective
treatments for manic-depressive illness (bi-polar disorder).
- Bipolar Disorder
- Bipolar disorder is a severe mood disorder
characterized by manic or depressive episodes that usually cycle
back and forth between depression and mania. The depressive phase
is characterized by sluggishness (inertia), loss of self-esteem,
helplessness, withdrawal and sadness, with suicide being a risk.
The manic phase is characterized by elation, hyperactivity, over-involvement
in activities, inflated self-esteem, a tendency to be easily
distracted, and little need for sleep. In either phase there
is frequently a dependence on alcohol or other substances of
abuse. The disorder first appears between the ages of 15 and
25 and affects men and women equally. The cause is unknown, but
hereditary and psychological factors may play a role. The incidence
is higher in relatives of people with bipolar disorders. A psychiatric
history of mood swings, and an observation of current behavior
and mood are important in the diagnosis of this disorder.7
- Hospitalization may be required during an
acute phase to control the symptoms of Bipolar Disorder. Antidepressant
drugs may be given; anticonvulsants (Carbamazepine, Valproic
acid, Depakote) may also be used. (These substances deplete body
stores of L-carnitine and Taurine. Supplementation with several
grams daily of these supplements greatly ameliorates adverse
side effects of these drugs).
- Lithium, however, is the treatment of choice
for recurring bipolar (manic/depressive) illness, serving as
an effective mood enhancer in 70-80 percent of bipolar patients.
- Mortality-lowering, Anti-suicidal Effect
of Lithium Orotate
- The mortality of manic-depressive patients
is markedly higher than that of the general population. The increased
mortality is mainly, but not exclusively, caused by suicide.
Studies have shown that the mortality of manic-depressive patients
given long-term lithium treatment is markedly lower than that
of patients not receiving lithium. The frequency of suicidal
acts among treated patients is significantly lower than patients
given other antidepressants or carbamazepine. The results of
mortality studies are consistent with the assumption that lithium-treatment
protects against suicidal behavior. 8-13
- Unipolar Disorder
- In addition to its well-recognized benefits
in the management of bipolar disorder, trials have conclusively
demonstrated that lithium is also an effective treatment for
recurrent unipolar depressive illness (recurrent major affective
disorder).14-16 Although physicians in Europe have successfully
used lithium for this indication for many years, American psychiatrists
do not share their appreciation of lithium's safety and effectiveness
for conditions other than MDI. Perhaps it is due to a difference
in the lithium preparations they have at their disposal.
- Superiority of Lithium Orotate
- The lithium salt of orotic acid (lithium
orotate/ vitamin B13) improves the specific effects of lithium
many-fold by increasing lithium bio-utilization. The orotates
transport the lithium to the membranes of mitochondria, lysosomes
and the glia cells. Lithium orotate stabilizes the lysosomal
membranes and prevents the enzyme reactions that are responsible
for the sodium depletion and dehydration effects of other lithium
salts. Because of the superior bioavailability of lithium orotate,
the therapeutic dosage is much less than prescription forms of
lithium. For example, in cases of severe depression, the therapeutic
dosage of lithium orotate is 150 mg/day. This is compared to
900-1800 mg of the prescription forms. In this dosage range of
lithium orotate, there are no adverse lithium side reactions
and no need for monitoring blood serum measurements.17
- Other Uses for Lithium Orotate
- Lithium Orotate has also been used with success
in alleviating the pain from migraine and cluster headaches,
low white blood counts, juvenile convulsive disease, alcoholism
and liver disorders.18 Nieper also reports that patients with
myopia (nearsightedness) and glaucoma often benefit from the
slight dehydrating effect of lithium on the eye, resulting in
improvement in vision and reduction of intraocular pressure.17
- 1. Aronson JK, Reynolds DJM. ABC of monitoring
drag therapy: lithium. BMJ. 1992;305: 1273-1276.
- 2. Schou M, Effects of long-term lithium
treatment on kidney function: an overview. J Psychiat Res, 1988;22.,287-296,
- 3. Waller DG, Edwards TG. Lithium and the
kidney: an update. Psycliol Mod. 1989; 19:825-83 1.
- 4. Gitlin MJ. Lithium-induced renal insufficiency.,
J Clin Psychopharmacol. 1993) 13:276-279.
- 5, Kallner G,.Petterson IJ. Renal, thyroid
and parathyroid function during lithium treatment: laboratory
test in 207 people treated for 1-30 years. Acta Psychiatr Scand.
- 6. Baastrup PC, Schou M. Lithium as a prophylactic
agent: its effect against recurrent depressions and manic-depressive
psychosis. Arch Gen Psychiatry. 1967; 16:162-172.
- 7. Goodwin FK, Jamison KR. Manic-Depressive
Illness. Oxford, England: Oxford University Press; 1990.
- 8. Mueller-Oerlinghausen D, Ahrens B, Volk
J, Grof P, Grof E, Schou M, Vestergaard P, Lenz G, Sinihandl
C, Tlau K, Wolf R. Reduced mortality of manic-depressive patients
in long-term lithium treatment, an international collaborative
study by IGSLI. Psychiatry Res. 1991;36:329-331.
- 9. Ahrens B, Mueller-Oerlinghausen 3, Schou
M, Wolf T, Alda M, Grof. E. Grof P, Lejiz G, Simhandl C, Thau
K, Vestergaard P, Wolf R, Moeller H. Cardiovascular and suicide
mortality of affective disorders may be reduced by lithium prophylaxis.
J Affect DI-Y, 1995;33:67-75.
- 10. Mueller-Oerlinghausen B, Mueser-Causemam
B, Volk J. Suicides and parasuicides in a high-risk patient group
on and off lithium long-term medication, J Affect Dis. 1992;25:
- 11. Felber- NV, Kyber A. Suizide und Parasuizide
wachrend und aubetadserhalb einer Lithiumprophylaxe. In-, Muclicr-Oerlinghausen
B, Berghoefer A, eds. Ziele und Ergebnisse der medikagivitoeseyi
I-i-opiiylaice affektiver Psychoseii. Stuttgart, Germany, Thieme;
- 12. Thies-Flechtner K, Seibert W, Walther
A, Greil W, Mueller-Oerlinghausen B, Suizide bei rezldlvprophylaktisch
behandelten Patienten mit affektiven Psychosen. In: Mueller-Oerlinghausen
B, Berghoefer A, eds. Ziele und Ergebnisse der medikamentoesen
Prophylaxe offekliver Psychosen. Stuttgart, Germany. Thieme;
- 13. Schou M.. Mortality-lowering effect of
prophylactic lithium treatment, a look at the evidence, Pharmacopsychiatry.
- 14. Souza FGM, Goodwin GM. Lithium treatment
and prophylaxis in unipolar depression: a meta-analysis, Br J
Psychiatry. 1991; 158:666-675.
- 15. Johnstone EC, Owens DGC, Lambert MT,
Crow TJ, Frith CD, Done DJ. Combination tricyclic, antidepressant
and lithium maintenance medication in unipolar and bipolar depressed
patients. J Affect Dis, 1990;20:225-233,
- 16. Prien RF, Kupfer DJ, Mansky PA, Small
JG, 'I'uason VB, Voss CB, Johnson WE. Drug therapy in the prevention
of recurrences in unipolar and bipolar affective disorders. Arch
Gen Psychiatry, 1984;41.1096-1104,
- 17. Nieper HA The clinical application of
lithium orotate. Agressologie 14(6). 407-411, 1973,
- 18. Sartori HE, Lithium orotate in the treatment
of alcoholism and related conditions, Alcohol 1986 Mar; 3 (2):
- 19. Nieper HA The curative effect of a combination
of Calcium-orotate and Lithium orotate on primary and secondary
chronic hepatitis and primary and secondary liver cirrhosis.
From lecture Intl Acad of Prevent Med, Washington, DC March 9,
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