Dr.Nieper's Lithium Orotate (LiOr)
Elemental Lithium Bond to Orotic Acid (vitamin B13)
Patented & Manufactured by the Nieper Licensed Formulary in the USA

Books by Dr.Hans Nieper, M.D.
--RARE & OUT OF PRINT-- Available from us at a reasonable price since we're an authorized trained Nieper affiliate.
Supplement Facts
Serving Size: 1 tablet
No. Servings: 100 tablets
Each nano-vortex enterically coated particles and tablet contains
Per Serving
Tablet size: 120 mg. (NOT 120 mg. of Lithium O.)
Active Ingredient per Tablet: 4.6 mg. of Elemental Lithium salts per tablet.
Bound to Orotic Acid (B13) & timed released tableting agents
Other Ingredients: Duratex, Pure Food Glaze, Plasdone, Ac-Di-Sol, Mag. Stearate, Compritol and Avicel. (enteric coating agents; tableting agents, timed release agents). Each particle is enteric coated & the tablet is also enteric coated for release in sm.intestine only.
Ý = no dietary value established
% DV
Use Instructions:
1 tab 2-3 times per day between meals.
Note: Individuals who are using antidepressants should be advised that receptors will be blocked and it may take higher doses for awhile (2-3 tablets several times per day) to achieve desired effects. Then reduce to maintenance dose. It is not recommended in acute unstable bipolar disorder to discontinue prescription medications without the assistance of a qualified physician who uses nutrition and orthomolecular therapies.
Cautions: Lithium is a natural diuretic and so be sure to drink plenty of water. Non-Orotate forms of Lithium should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation or dehydration, or sodium depletion, and by individuals who are taking diuretics or ACE inhibitors. Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs or insulin or thyroid. Lithium should not be used by pregnant women and breast-feeding mothers. Keep away from children.
Packaging & Sizes
100 tablets $12.50
200 tablets $21.50
3 Pack $59.95

Notes: General rule of thumb for those using benzodiazapines and other antidepressants: most do not realize that the drugs themselves can cause the symptoms of depression and even suicide ! Natural alternative minerals are a much better choice once the patient is stable. Working with a psyciatrist/MD who deals with depression and use applied clinical nutrition in their practices is critical to a good transition...We recommend Dr. Hyla Cass in Pacific Palisades, CA. Also evaluation for heavy metal & dental toxicity is highly recommended. See the book "The Roots of Disease" by Stephen Levy, M.D. & Robert Kulacz, D.D.S. for more information. Also severe Magnesium deficiencies can manifest in mood and emotional disorders, even schitzophrenia. Check out Dr.Carol Dean's book "The Miracle of Magnesium" for more information. Oral Magnesium frequently is not enough to affect acute conditions. IV, oral and topical is needed.
Lithium Orotate is targeted to the mitrochondria and only functions there. As a result, it does not show up in blood tests. Orotate forms of lithium are approximately 20 fold more effective than toxic synthetic lithium. If trying to use the natural Lithium to replace synthetic Lithium carbonate or sulphate, take approx double or triple the suggested dosing. So 1-2 tabs 3 or 4 times per day until stabile and then back down to whatever is necessary to maintain metabolic equilibrium. Maintenance is usually 1 cap twice daily.
Benefits: Lithium is one of the minerals used by the brain to balance brain functions. Many doctors use compound forms of Lithium for treating various kinds of brain dysfunction problems. Different compound formulas of Lithium have many different effects on the brain, but the majority of harmful effects are due to the compound formula itself, and not to the actual Lithium. Lithium in the elemental form has never been shown to have major side effects.
Lithium, when combined with germanium, greatly aids the electrical transfer within the brain itself. Lithium should be used in conjunction with magnesium. Magnesium aids in the electrical transfer that the Lithium causes to happen.
Uses of Natural Lithium Orotate As Described by Dr.Nieper

We only use Dr.Han's Neiper Lithium formulations which are non toxic and do not require blood test monitoring by a physician to prevent kidney damage by the pharmaceutical formulas

Lithium Orotate
The Unique, Safe Mineral with Multiple Uses
by Ward Dean, M.D. and Jim English
July 1999

Lithium is a mineral with a cloudy reputation. It is an alkali metal in the same family as sodium, potassium and other elements. Although lithium is highly effective in the treatment of manic depressive illness (X4 DI), its pharmaceutical (prescription) versions, lithium carbonate and lithium citrate, must be used with caution. The reason for the caution with prescription lithium (RX) is because lithium in these forms is poorly absorbed by the cells of the body - and it is within the cells that lithium's therapeutic effects take place. Lithium ions are believed to act only at particular sites on the membranes of intracellular structures like mitochondria and lysosomes.
Consequently, because of this poor intracellular transport, high dosages of pharmaceutical forms of lithium must be taken in order to obtain a satisfactory therapeutic effect. Unfortunately, these therapeutic dosages cause blood levels to be so high that they border on toxic levels. Consequently, patients taking prescription lithium must be closely monitored for toxic blood levels. Serum lithium and serum creatinine levels of prescription lithium-treated patients should be monitored every 3-6 months.
Toxic effects of RX lithium may include hand tremors, frequent urination, thirst, nausea, and vomiting. Even higher doses may cause drowsiness, muscular weakness, poor coordination, ringing in the ears, blurred vision, and other symptoms.
There has been concern that long-term RX lithium treatment may damage kidney function, but data in this regard are equivocal. Renal insufficiency without a known cause has occurred in the general population, and the incidence of renal failure among manic-depressive patients not treated with lithium remains unknown.
Most patients treated with RX lithium are also taking other medications, and it is just as likely that the few known cases of renal failure in patients taking lithium were due to other medications that they were simultaneously taking.2-5
Nevertheless, with potential side effects like this, why in the world would anyone want to take lithium? It is because lithium has been found to be one of the most effective treatments for manic-depressive illness (bi-polar disorder).
Bipolar Disorder
Bipolar disorder is a severe mood disorder characterized by manic or depressive episodes that usually cycle back and forth between depression and mania. The depressive phase is characterized by sluggishness (inertia), loss of self-esteem, helplessness, withdrawal and sadness, with suicide being a risk. The manic phase is characterized by elation, hyperactivity, over-involvement in activities, inflated self-esteem, a tendency to be easily distracted, and little need for sleep. In either phase there is frequently a dependence on alcohol or other substances of abuse. The disorder first appears between the ages of 15 and 25 and affects men and women equally. The cause is unknown, but hereditary and psychological factors may play a role. The incidence is higher in relatives of people with bipolar disorders. A psychiatric history of mood swings, and an observation of current behavior and mood are important in the diagnosis of this disorder.7
Hospitalization may be required during an acute phase to control the symptoms of Bipolar Disorder. Antidepressant drugs may be given; anticonvulsants (Carbamazepine, Valproic acid, Depakote) may also be used. (These substances deplete body stores of L-carnitine and Taurine. Supplementation with several grams daily of these supplements greatly ameliorates adverse side effects of these drugs).
Lithium, however, is the treatment of choice for recurring bipolar (manic/depressive) illness, serving as an effective mood enhancer in 70-80 percent of bipolar patients.
Mortality-lowering, Anti-suicidal Effect of Lithium Orotate
The mortality of manic-depressive patients is markedly higher than that of the general population. The increased mortality is mainly, but not exclusively, caused by suicide. Studies have shown that the mortality of manic-depressive patients given long-term lithium treatment is markedly lower than that of patients not receiving lithium. The frequency of suicidal acts among treated patients is significantly lower than patients given other antidepressants or carbamazepine. The results of mortality studies are consistent with the assumption that lithium-treatment protects against suicidal behavior. 8-13
Unipolar Disorder
In addition to its well-recognized benefits in the management of bipolar disorder, trials have conclusively demonstrated that lithium is also an effective treatment for recurrent unipolar depressive illness (recurrent major affective disorder).14-16 Although physicians in Europe have successfully used lithium for this indication for many years, American psychiatrists do not share their appreciation of lithium's safety and effectiveness for conditions other than MDI. Perhaps it is due to a difference in the lithium preparations they have at their disposal.
Superiority of Lithium Orotate
The lithium salt of orotic acid (lithium orotate/ vitamin B13) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts. Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium. For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements.17
Other Uses for Lithium Orotate
Lithium Orotate has also been used with success in alleviating the pain from migraine and cluster headaches, low white blood counts, juvenile convulsive disease, alcoholism and liver disorders.18 Nieper also reports that patients with myopia (nearsightedness) and glaucoma often benefit from the slight dehydrating effect of lithium on the eye, resulting in improvement in vision and reduction of intraocular pressure.17

  • LITHIUM PROTECTS FROM BRAIN DAMAGE FROM ENVIRONMENTAL TOXINS Lancet Reports Wayne State University in Detroit found that lithium has the ability to both protect and renew brain cells.(1) Nonaka, S., C.J. Hough, and D. Chuang. 1998. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proceedings of the National Academy of Sciences 95(March 3):2641.
  • LITHIUM INCREASES GREY BRAIN MATTER (reversing brain atrophy). 8 out of 10 who took lithium showd an average of 3 percent increase in brain grey matter in just 4 weeks http://www.med.wayne.edu/press/2000/press36.htm
  • LITHIUM ENHANCES NERVE CELL DNA REPLICATION. DNA replication is the first step in cellular formation of any type.
  • LITHIUM BLOCKS DEVELOPMENT AND ADVANCEMENT OF ALZHEIMERS May 22, 2003: Lithium Blocks Alzheimer Pathology http://www.alz.org/WhatsNew/052203lithium.htm (Alzheimer's Assoc. site)
  • LITHIUN INHIBITS OVERACTIVATION OF A BRAIN PROTEIN called the "tau" protein wich contributes to degeneration Alzheimer's. http://www.jneurochem.org/cgi/content/abstract/73/5/2073
  • LITHIUM INHIBITS NEUROFIBRILLARY TANGLES, another degenerative cause in Alzheimer's http://www.nimh.nih.gov/events/prlithium.cfm

  • References

    1. Aronson JK, Reynolds DJM. ABC of monitoring drag therapy: lithium. BMJ. 1992;305: 1273-1276.
    2. Schou M, Effects of long-term lithium treatment on kidney function: an overview. J Psychiat Res, 1988;22.,287-296,
    3. Waller DG, Edwards TG. Lithium and the kidney: an update. Psycliol Mod. 1989; 19:825-83 1.
    4. Gitlin MJ. Lithium-induced renal insufficiency., J Clin Psychopharmacol. 1993) 13:276-279.
    5, Kallner G,.Petterson IJ. Renal, thyroid and parathyroid function during lithium treatment: laboratory test in 207 people treated for 1-30 years. Acta Psychiatr Scand. 1995;91:48-5 1.
    6. Baastrup PC, Schou M. Lithium as a prophylactic agent: its effect against recurrent depressions and manic-depressive psychosis. Arch Gen Psychiatry. 1967; 16:162-172.
    7. Goodwin FK, Jamison KR. Manic-Depressive Illness. Oxford, England: Oxford University Press; 1990.
    8. Mueller-Oerlinghausen D, Ahrens B, Volk J, Grof P, Grof E, Schou M, Vestergaard P, Lenz G, Sinihandl C, Tlau K, Wolf R. Reduced mortality of manic-depressive patients in long-term lithium treatment, an international collaborative study by IGSLI. Psychiatry Res. 1991;36:329-331.
    9. Ahrens B, Mueller-Oerlinghausen 3, Schou M, Wolf T, Alda M, Grof. E. Grof P, Lejiz G, Simhandl C, Thau K, Vestergaard P, Wolf R, Moeller H. Cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. J Affect DI-Y, 1995;33:67-75.
    10. Mueller-Oerlinghausen B, Mueser-Causemam B, Volk J. Suicides and parasuicides in a high-risk patient group on and off lithium long-term medication, J Affect Dis. 1992;25: 261-270.
    11. Felber- NV, Kyber A. Suizide und Parasuizide wachrend und aubetadserhalb einer Lithiumprophylaxe. In-, Muclicr-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikagivitoeseyi I-i-opiiylaice affektiver Psychoseii. Stuttgart, Germany, Thieme; 1994:53-59.
    12. Thies-Flechtner K, Seibert W, Walther A, Greil W, Mueller-Oerlinghausen B, Suizide bei rezldlvprophylaktisch behandelten Patienten mit affektiven Psychosen. In: Mueller-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikamentoesen Prophylaxe offekliver Psychosen. Stuttgart, Germany. Thieme; 1994,61-64.
    13. Schou M.. Mortality-lowering effect of prophylactic lithium treatment, a look at the evidence, Pharmacopsychiatry. 1995;28: 1.
    14. Souza FGM, Goodwin GM. Lithium treatment and prophylaxis in unipolar depression: a meta-analysis, Br J Psychiatry. 1991; 158:666-675.
    15. Johnstone EC, Owens DGC, Lambert MT, Crow TJ, Frith CD, Done DJ. Combination tricyclic, antidepressant and lithium maintenance medication in unipolar and bipolar depressed patients. J Affect Dis, 1990;20:225-233,
    16. Prien RF, Kupfer DJ, Mansky PA, Small JG, 'I'uason VB, Voss CB, Johnson WE. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Arch Gen Psychiatry, 1984;41.1096-1104,
    17. Nieper HA The clinical application of lithium orotate. Agressologie 14(6). 407-411, 1973,
    18. Sartori HE, Lithium orotate in the treatment of alcoholism and related conditions, Alcohol 1986 Mar; 3 (2): 97-100.
    19. Nieper HA The curative effect of a combination of Calcium-orotate and Lithium orotate on primary and secondary chronic hepatitis and primary and secondary liver cirrhosis. From lecture Intl Acad of Prevent Med, Washington, DC March 9, 1974.

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